We have seen no issues with our skins / Thesis 1.7 and the WordPress 3.0 upgrade. However, to be safe always be sure to follow the recommended steps before upgrading – but you all do that anyways right? 
http://codex.wordpress.org/Updating_WordPress
Update: Don Gilbert let us know that there is an issue with the Thesis custom file editor and WP 3.0 – if you need that feature you may want to wait until diythemes.com releases a fix.
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Mark Hodder has been a successful web freelancer since 2007. His business, Hodder Consulting, works with small / medium businesses all over the world to provide cost effective solutions to common IT problems. After implementing the popular WordPress framework "Thesis" with great success on many of his clients sites he launched ThesisThemes.com on June 1, 2009.
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